Janet Lindow, PhD, has research experience in a broad range of fields including clinical trial management, mental health interventions, translational immunology, vaccine development, and basic research in microbiology and biochemistry. Throughout her career, she has applied novel translational research approaches to identify and/or evaluate new preventative treatments and diagnostic tests for diseases with large public health impact in the US and internationally. Dr. Lindow has received multiple NIH and international grants and fellowships to support her research. As a dedicated educator, she has also helped mentor over 30 undergraduate and graduate students.
Before switching to mental health research, Dr. Lindow’s research focused on neglected tropical diseases. As an Assistant Professor at the Center of Biomedical Research Excellence (COBRE), University of Vermont, she developed translational research programs for infectious diseases and assisted with the design and performance of early phase vaccine clinical trials. In 2013, she was recruited to Yale University and was stationed in Salvador, Brazil where she developed a translational research program in an infectious disease associated with urban poverty. Working collaboratively with her Brazilian colleagues, she helped build research capacity, worked with vulnerable populations in urban slums, and participated in multidisciplinary field and hospital clinical studies. Her team’s research led to the discovery of a potential new therapeutic for severe leptospirosis.
In 2016, Dr. Lindow was recruited to the Montana State University Center for Mental Health Research and Recovery. In collaboration with Matt Byerly, MD, her research efforts at Montana State aimed to prevent suicide and reduce risk factors associated with suicide, such as depression and anxiety. She and Dr. Byerly moved their suicide prevention program to the University of Arizona in 2018.
Dr. Lindow works to develop and evaluate interventions to increase mental health resiliency and reduce suicidality, a major US public health problem. Her work is divided into three topics:
Mental Health Resilience and Suicide Prevention among Native American Children – Good Behavior Game: Dr. Lindow and Vikki Howard, PhD (University of Montana – Western) have an NIH-funded pilot project evaluating an evidence-based suicide prevention intervention for young children, the Good Behavior Game, in preschool-aged children living in a Native American community in Montana.
Treating Suicide Risk Factors in US Military Veterans – Thrive for Veterans: Dr. Lindow, Dr. Byerly, and colleagues are tailoring an evidence-based, digital intervention for depression for military veterans. They plan to test whether the digital program can reduce the high rates of suicide in veteran populations.
Suicide Prevention among US Adolescents – Youth Aware of Mental Health: Dr. Lindow collaborated with Dr. Byerly on 2 pilot studies assessing the feasibility and efficacy of a leading universal, school-based suicide prevention intervention, Youth Aware of Mental Health, in adolescents in Montana.
Lindow JC, Hughes JL, South C, Minjahuddin A, Gutierrez L, Bannister E, Trivedi MH, and Byerly MJ. The Youth Aware of Mental Health (YAM) intervention: impact on help-seeking, mental health knowledge, and stigma in US adolescents. 2020. In press. doi:10.1016/j.jadohealth.2020.01.006.
Lindow JC, Becker MN, Nakonezny PA, and Byerly MJ. Evaluating an Anti-stigma Intervention Combining Personal Account with Musical Performance among Rural Adolescents. J Rural Mental Health, 43(4), 130–137. 10.1037/rmh0000122
Schure MB, Lindow JC, Greist JH, Nakonezny PA, Bailey SJ, Bryan B, and MJ Byerly. A Randomized Controlled Trial of a Fully Automated Internet-Based Cognitive Behavior Therapy Intervention in a Community Population of Adults with Depression Symptoms. J Med Internet Res. 2019 Nov 18;21(11):e14754. doi: 10.2196/14754. PMID: 31738173
Lindow JC, Hughes JL, South C, Gutierrez L, Bannister E, Trivedi MH, and Byerly MJ. Feasibility and acceptability of the Youth Aware of Mental Health (YAM) intervention in US adolescents. Arch Suicide Res, 2019, 4:1-16. 10.1080/13811118.2019.1624667. PMID: 31159674
Hughes JL, Trivedi MH, Byerly MJ, Lindow JC, South C. Feasibility and acceptability of the Youth Aware of Mental Health (YAM) program in the United States: impact on resilience and depressive symptoms. Symposium presentation at American Psychological Association Meeting, San Francisco, CA, 2018.
Byerly MJ, Lindow JC, Hughes JL, South C, Trivedi MH. Feasibility and acceptability of implementing the Youth Aware of Mental Health (YAM) intervention in Native American School Settings. European Symposium on Suicide & Suicidal Behavior, Belgium, 2018
Lindow JC, Wunder EA, Popper SJ, Min J, Mannam P, Srivastava A, Yao Y, Hacker KP, Raddassi K, Lee PJ, Montgomery RR, Shaw AC, Hagan JE, Araújo GC, Nery N, Relman DA, Kim CC, Reis MG, Ko AI. Cathelicidin insufficiency in patients with fatal leptospirosis. PLoS Pathogens 2016;12(11): e1005943. doi: 10.1371/journal.ppat.1005943. PMCID: PMC5094754. Press release: http://medicine.yale.edu/news/article.aspx?id=13811
Nery NRR Jr, Claro DB, Lindow JC. Prediction of Leptospirosis Cases using Classification Algorithms. IET Software, 2017. DOI: http://dx.doi.org/10.1049/iet-sen.2016.0193.
Lessa-Aquino C, Lindow JC, Randall A, Wunder E, Pablo J, Nakajima R, et al. Distinct antibody responses of patients with mild and severe leptospirosis determined by whole proteome microarray analysis. PLoS Negl Trop Dis 2017; 11(1):e0005349. doi: 10.1371/journal.pntd.0005349. PMCID: PMC5302828.
Backstedt BT, Buyuktanir O, Lindow JC, Wunder Jr EA, Reis MG, Usmani-Brown S, Ledizet M, Ko A, Pal U. Efficient Detection of Pathogenic Leptospires Using 16S Ribosomal RNA. PLoS One 2015; 10(6):e0128913. doi: 10.1371/journal.pone.0128913. PMCID: PMC4474562.
Popper SJ, Strouts FR, Lindow JC, Cheng H, Balmaseda H, Harris E, Kirkpatrick BD, Durbin AP, Whitehead SS, and Relman DA. Early transcriptional correlates of immunity after dengue vaccination and infection in humans. J Inf Dis, 2018. doi: 10.1093/infdis/jiy434. PMID: 30010906.
Lindow JC, Borochoff-Porte N, Durbin AP, Whitehead SS, Fimlaid KA, Bunn JY, and BD Kirkpatrick. Primary Vaccination with Low Dose Live Dengue 1 Virus Generates a Proinflammatory, Multifunctional T Cell Response in Humans. PLoS Negl Trop Dis 2012; 6(7): e1742. PMCID: PMC3398956.
Durbin AP, Kirkpatrick BD, Pierce KK, Elwood D, Larsson CJ, Lindow JC, Tibery C, Sabundayo BP, Shaffer D, Talaat KR, Hynes NA, Wanionek K, Carmolli MP, Luke CJ, Murphy BR, Subbarao K, Whitehead SS. A single dose of any of four different live attenuated tetravalent dengue vaccines is safe and immunogenic in flavivirus-naive adults: a randomized, double-blind clinical trial. J Infect Dis. 2013; 207(6):957-65. doi: 10.1093/infdis/jis936. PMCID: PMC3571448.
Weiskopf D, Angelo MA, Bangs D, Signey J, Paul S, Peters B, de Silva AD, Lindow JC, Whitehead SS, Durbin AP, Kirkpatrick BD, Sette A. Tetravalent dengue live attenuated vaccine induce multifunctional CD8+ T cell responses against highly conserved epitopes. J Virol 2015; 89(1):120-8. PMCID: PMC4301095.
Lindow JC, Fimlaid, KA, Bunn, JY and Kirkpatrick BD. Antibodies in action: the role of human opsonins in killing Salmonella enterica serovar Typhi. Infect Immun 2011; 79 (8):3188-94. PMCID: PMC3147595.
Lindow JC, Poly, F, Tribble DR, Guerry P, Carmolli MP, Baqar S, Porter CK, Pierce KK, Darsley MJ, Sadigh KS, Dill EA, The Campylobacter Study Team, Kirkpatrick BD. Caught in the act: In vivo development of macrolide resistance to Campylobacter jejuni infection. J Clin Microbiol 2010; 48(8):3012. PMCID: PMC2916616.
Lindow JC, Dohrmann PR, McHenry CS. DNA Polymerase α Subunit Residues and Interactions Required for Efficient Initiation Complex Formation Identified by a Genetic Selection. J Biol Chem 2015; 290(27):16851-60. PMCID: PMC4505431. Featured in Virtual Issue: DNA Polymerases, Damage and Repair: http://www.jbc.org/site/vi/dna.xhtml
Lindow JC, Kuwano M, Moriya S, and Grossman AD. Subcellular localization of the Bacillus subtilis Structural Maintenance of Chromosomes (SMC) protein. Mol Microbiol 2002; 46:997-1009. PMID: 12421306.
Lindow JC, Britton RA, and Grossman AD. Structural Maintenance of Chromosomes protein of Bacillus subtilis affects supercoiling in vivo. J Bacteriol 2002; 184 (19):5317-5322. PMCID: PMC135370.